Hydroxyzine HCl Oral: Uses, Side Effects, Interactions, Precautions and Overdose

Hydroxyzine HCl is an antihistamine that can be used for various purposes. Here’s a brief overview:


  1. Allergies: It can be used to relieve itching and allergic reactions.
  2. Anxiety: It may be prescribed for anxiety and tension.
  3. Sedation: Due to its sedative effects, it’s sometimes used as a pre-anesthetic to prepare patients for surgery.
  4. Itching: It’s effective in treating itching caused by various allergic reactions.
  5. Insomnia: In some cases, it’s used for its sedative properties to treat insomnia.

Side Effects:

  1. Common Side Effects: Drowsiness, dizziness, blurred vision, dry mouth.
  2. Serious Side Effects: Irregular heartbeat, mental/mood changes (e.g., agitation, aggression, mood swings, depression).


  1. Drug Interactions: Hydroxyzine may interact with other medications, including certain antidepressants, antihistamines, and muscle relaxants.
  2. Alcohol: It can enhance the sedative effects of alcohol.


  1. Allergies: Inform your doctor about any allergies to hydroxyzine or other antihistamines.
  2. Medical History: Discuss your medical history, especially of breathing problems, glaucoma, heart problems, liver disease, and seizures.
  3. Pregnancy and Breastfeeding: Consult with your healthcare provider if you are pregnant or breastfeeding.

Overdose: In case of overdose, symptoms may include severe drowsiness, seizures, or very slow breathing. Seek immediate medical attention. The antidote for overdose is usually physostigmine or activated charcoal.

Remember, this information is not a substitute for professional medical advice. Always consult with your healthcare provider for personalized guidance based on your health condition and history.