CREATINE: Overview, Uses, Side Effects, Precautions, Interactions and Dosing

Creatine is a naturally occurring compound found in small amounts in certain foods and synthesized by the body, primarily in the liver, kidneys, and pancreas. It plays a crucial role in the production of energy during high-intensity, short-duration activities, such as weightlifting and sprinting. Creatine supplements are commonly used by athletes and fitness enthusiasts to improve physical performance. Here is an overview of creatine, its uses, side effects, precautions, interactions, and dosing:


  1. Enhancing Physical Performance: Creatine supplements are commonly used by athletes to increase their muscle strength and power, improve exercise performance, and facilitate faster recovery.
  2. Muscle Building: Creatine may help promote muscle growth and increase muscle mass, which can be beneficial for bodybuilders and strength athletes.
  3. Neurological Health: Some research suggests that creatine might have potential benefits for certain neurological conditions, such as Parkinson’s disease and traumatic brain injury. However, more research is needed in this area.

Side Effects:

Creatine is generally considered safe when used as directed, but some people may experience mild side effects, including:

  • Gastrointestinal distress (e.g., stomach cramps, diarrhea).
  • Dehydration if not consumed with sufficient water.
  • Weight gain, which is often due to increased water retention in muscles.


  • Creatine supplements may not be suitable for individuals with pre-existing kidney or liver conditions, as the kidneys play a role in creatine excretion.
  • Individuals with a history of kidney stones should use creatine with caution and under medical supervision.
  • Pregnant and breastfeeding women should consult a healthcare professional before using creatine supplements.


  • Creatine can interact with certain medications or supplements. Consult with a healthcare provider if you are taking diuretics (water pills), nonsteroidal anti-inflammatory drugs (NSAIDs), or other medications that may affect kidney function.


  • The most common dosing regimen is to begin with a “loading phase” of 20 grams per day (divided into 4 doses) for 5-7 days, followed by a “maintenance phase” of 3-5 grams per day.
  • Alternatively, some individuals skip the loading phase and take 3-5 grams of creatine per day from the start.
  • Creatine monohydrate is the most studied and widely used form of creatine.

It’s essential to follow recommended dosing guidelines and stay well-hydrated while using creatine. As with any dietary supplement, it’s advisable to consult with a healthcare professional or a sports nutritionist before starting creatine supplementation, especially if you have any underlying health conditions or concerns about potential interactions with other substances.

Keep in mind that individual responses to creatine supplementation may vary, and the benefits may not be equally significant for everyone.